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L-Citrulline for Blood Pressure: Doses and Results
L-citrulline for blood pressure was tested in 8 trials using 3 to 9 g a day. Together they found systolic pressure about 4.1 mm Hg lower, while the diastolic change was not statistically significant. That is a trial result, not a treatment. Melonex capsules hold much less citrulline than that.
Written by the Melonex label deskUpdated · 4 min read
What do trials say about L-citrulline for blood pressure?
A pooled analysis of 8 trials found L-citrulline went with a small drop in systolic pressure. Doses ranged from 3 to 9 g a day (Barkhidarian 2019, citrulline meta-analysis).
The diastolic drop of 2.08 mm Hg was not statistically significant overall. In studies using 6 g a day or more, diastolic fell by 2.75 mm Hg (Barkhidarian 2019, citrulline meta-analysis).
| Measure | Average change | Significant? |
|---|---|---|
| Systolic | -4.10 mm Hg | Yes |
| Diastolic | -2.08 mm Hg | No |
| Diastolic, 6 g or more | -2.75 mm Hg | Yes |
Is the evidence for citrulline settled?
No. A review found citrulline's effect on blood pressure more questionable than arginine's. Meta-analyses disagree, and one of five trials found no significant change (Khalaf 2019, arginine and citrulline).
A single 10 g dose did not improve vessel function in older adults with heart failure (Aguayo 2021, L-citrulline review). Mixed results are the honest summary.
Why use citrulline instead of arginine?
Citrulline is used because the body turns it into arginine, and it raises blood arginine more than arginine itself does (Schwedhelm 2008, citrulline kinetics). Kidneys convert about 83% of it (Aguayo 2021, L-citrulline review).
Swallow
Citrulline passes the liver and gut unchanged.
Convert
The kidneys make arginine.
Signal
Arginine feeds nitric oxide.
Melonex: from $49 a bottle60 capsules · 2, 3 or 6 bottles · free US shipping on 3 or 6 · 60-day guarantee
See packsHow much citrulline is in a Melonex capsule?
A Melonex capsule holds between about 167 and 500 mg of citrulline malate, and the single amount is not printed. Part of that weight is the malate.
Two capsules give at most 1 g of citrulline malate, against 3 g or more in the trials. No study has tested Melonex. Keep taking prescribed medicine, and ask your doctor first if you take blood pressure drugs, nitrates or sildenafil (Mayo Clinic, L-arginine).
Which packs cost the least?
The larger packs carry the lowest price per bottle.
Free US shipping3 bottles · $207$69 a bottle · 180 days at 1 capsule a day · free US shippingChoose 3 bottles
Lowest per bottle6 bottles · $294$49 a bottle · 360 days at 1 capsule a day · free US shippingChoose 6 bottlesSales-page prices, October 18, 2026 (Melonex sales page). A 2-bottle pack is also sold ($158 plus $9.99 shipping). See every pack on the pricing page.
FDA disclaimer. These statements have not been evaluated by the Food and Drug Administration. Melonex is not intended to diagnose, treat, cure, or prevent any disease. Keep taking prescribed medicine, and ask your doctor before starting any supplement.
FAQ01
Melonex questions people ask
Does watermelon give the same effect as L-citrulline?
Not reliably. Watermelon holds roughly 0.7 to 3.6 g of citrulline per kg (Aguayo 2021, L-citrulline review), so you would need a lot of fruit, and trial results used supplements.
What is the usual citrulline dose in studies?
Studied doses ran from 1.5 g twice daily up to 6 to 10 g a day, with a single 15 g dose in one trial (Aguayo 2021, L-citrulline review).
Can citrulline replace blood pressure medicine?
No. The average drop was small and varied between studies, so a supplement is no substitute for the medicine your doctor prescribed.
Who wrote this02
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Pages built from the label, the sales page and linked NIH, FDA, AHA, CDC, FTC and peer-reviewed sources.
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