Starter
2 bottles120 capsules

$158total
$79 a bottle
- 2 capsules a day
- 60 days · about $2.63/day
- 1 capsule a day
- 120 days · about $1.32/day
$9.99 shipping
- 60 days at 2 capsules, 120 at 1
- $9.99 US shipping on this pack
- 60-day money-back guarantee
Official website · USA authorized Melonex retailer
Melonex is a capsule dietary supplement that pairs L-citrulline DL-malate with two forms of L-arginine in one 500 mg blend. The label says one capsule a day with 8 oz of water, up to two. These amino acids feed nitric oxide, which relaxes blood vessels. Trials used grams a day, and no study has tested Melonex itself.
Written by the Melonex label desk · Updated

The product
Melonex Advanced Support
60 capsules · 1 a day with water, up to 2
From $49 a bottle · free US shipping on 3 or 6
One capsule, one artery ring
Drawing, not dataAn artery in cross-section. The drawing shows the pathway the three ingredients feed (citrulline to arginine to nitric oxide), not what one capsule does in your body.
Dose check
14label lines
| Form | Capsules, plant-cellulose shell |
|---|---|
| Count | 60 capsules, 60 servings |
| Per capsule | 500 mg proprietary blend |
| Directions | 1 a day with 8 oz water, up to 2 |
| Distributor | Instituto Experience, Lakeland, FL |
| Price | From $49 a bottle |
| Guarantee | 60 days, claims after 30 |
What it is01
Melonex is a dietary supplement sold as capsules, 60 to a bottle. Each capsule holds one 500 mg proprietary blend of three amino acid forms: L-citrulline DL-malate, L-arginine alpha-ketoglutarate and L-arginine HCl.
The front of the bottle reads "Heart Support*", "Circulation Support*" and "Natural Formula*". The asterisk points to the standard FDA statement: these claims have not been evaluated, and the product is not meant to diagnose, treat, cure or prevent any disease (FDA, structure/function claims).
Melonex is not a blood pressure medicine. It also has nothing to do with the meloxicam painkiller sold under the same name in parts of South Asia, a point we explain further down.

Claims vs evidence02
Not in any study of Melonex, because none exists. Its ingredients have lowered readings a little, at doses many times higher.
No, there is no evidence that Melonex lowers blood pressure. Nobody has run a trial on the capsules. What exists are trials of the single ingredients.
Eleven trials of oral L-arginine at 4 to 24 g a day lowered systolic pressure by about 5.4 mm Hg and diastolic by about 2.7 (Dong 2011, arginine meta-analysis). L-citrulline at 3 to 9 g a day lowered systolic pressure by about 4.1 mm Hg (Barkhidarian 2019, citrulline meta-analysis). One Melonex capsule holds 0.5 g of the whole blend.
Claims as printed on the sales page (Melonex sales page) and the label. Health claims need competent and reliable scientific evidence, generally human trials of the same product (FTC, health products guidance).
Do not stop, skip or cut a blood pressure or heart medicine because you started a supplement. Arginine can add to those drugs and push pressure too low, so tell your doctor or pharmacist before you begin (Mayo Clinic, L-arginine).
How you take it03
One capsule with a full glass of water. The label allows a second one a day and stops there.
Take one capsule a day with an 8 oz glass of water. The label says you may take up to two capsules daily. It names no time of day and no link to meals, so pick a time you will remember.
A bottle holds 60 capsules. That is 60 days at one a day or 30 days at two. The sales page counts its supply the second way, two bottles for 60 days (Melonex sales page).
The label says not to use the bottle if the safety seal is damaged or missing. Look before you open a new one.
Swallow one capsule with a full glass of water. That is the label's base dose, and a bottle lasts 60 days at it.
The label allows a second capsule a day. Two a day is how the sales page counts its supply: 30 days a bottle.
Guarantee claims open after 30 days of use and close at 60 days. Share a home blood pressure log with your doctor.
Directions as printed: "As a dietary supplement, take one (1) capsule daily with an 8 oz. glass of water. May take up to two (2) capsules daily." More detail is on the how to take it page.
Ingredients04
Six label lines: a three-part 500 mg blend, then the capsule shell and two processing aids.
A Melonex capsule holds a 500 mg proprietary blend of L-citrulline DL-malate, L-arginine alpha-ketoglutarate dihydrate and L-arginine HCl, listed in that order. The other ingredients are a hydroxypropyl methylcellulose capsule, microcrystalline cellulose and magnesium stearate.
A proprietary blend only has to show its total weight and the order of its parts, from most to least (21 CFR 101.36, blends). So citrulline is the biggest share, and arginine HCl the smallest.
From the Supplement Facts panel and the other-ingredients line on the label. Lines 1-3 are the blend, listed from most to least by weight (21 CFR 101.36, blends). Lines 4-6 are the capsule shell and two processing aids.
Line 1 of 3Line 1 of 3: the largest share of the blend
L-citrulline (an amino acid first found in watermelon) bound to malic acid
Evidence: Small blood pressure drops in some trials; mixedAn illustration made for this site, not a product photo.
Not listed; line 1 of 3 in the 500 mg blend, so between about 167 and 500 mg per capsule
Studied atAbout 3-9 g a day of L-citrulline in blood pressure trials; 3 g or more before exercise in sports studies
Watch forMay add to blood pressure medicines, nitrates and erectile-dysfunction drugs.
Full profile
Line 2 of 3Line 2 of 3: at most 250 mg a capsule
L-arginine bound to alpha-ketoglutarate (often sold as AAKG)
Evidence: Small blood pressure drops in pooled trialsAn illustration made for this site, not a product photo.
Not listed; line 2 of 3 in the 500 mg blend, so at most 250 mg per capsule
Studied atAbout 4-24 g a day of L-arginine in blood pressure trials
Watch forNot for use after a heart attack; may add to blood pressure drugs, nitrates and sildenafil.
Full profile
Line 3 of 3Line 3 of 3: at most 167 mg a capsule
L-arginine as its hydrochloride salt
Evidence: Small blood pressure drops in pooled trialsAn illustration made for this site, not a product photo.
Not listed; line 3 of 3 in the 500 mg blend, so at most 167 mg per capsule
Studied atAbout 4-24 g a day of L-arginine in blood pressure trials
Watch forSame cautions as other arginine; stomach upset and bloating at higher doses.
Full profile
Not in the blendNot part of the blend
Capsule shell and two processing aids
Evidence: Not active ingredientsAn illustration made for this site; the real capsule's color is not shown in the brand images.
Not listed (not part of the blend)
Studied atNot studied as active ingredients
Watch forGenerally recognized as safe in food and supplement use
Full profileThe plates are illustrations made for this site. The full panel is on the supplement facts page.
The label05
Fifteen numbered spots on the flat label. Tap one to read that part in plain words; on a phone, the label scrolls sideways.
The label says Melonex is a dietary supplement of 60 capsules, one capsule per serving, with a 500 mg blend and no single amounts. It also carries the caution, the storage line, the made-in-USA line and the distributor: Instituto Experience of Lakeland, Florida.
The maker is not named. "Manufactured in an FDA registered facility" means the plant is registered with FDA, which is not the same as FDA approval (FDA, supplement Q&A).
Tap a number to read that part of the label.
One capsule a day with an 8 oz glass of water. Up to two a day. No time of day is printed.
Keep away from heat, light and humidity to preserve freshness.
Do not exceed the dose. Pregnant or nursing, under 18, or a known medical condition: ask a physician first.
Also: do not use if the safety seal is damaged or missing; store in a cool, dry place.
'Made in the USA with globally sourced ingredients.' The countries are not named.
Distributed for INSTITUTO EXPERIENCE, Lakeland FL 33804, +1 (507) 448-8190. The maker is not named.
A framed red dot between gold rules: brand art, not a seal or a certification.
Melonex, ADVANCED SUPPORT. 'Advanced' is brand wording; nothing on the label defines it.
'Heart Support*', 'Circulation Support*' and 'Natural Formula*', each with the FDA asterisk.
'60 CAPSULES', 'DIETARY SUPPLEMENT'. Sixty days at one a day, thirty at two.
1 capsule per serving, 60 servings per container.
500 mg for three ingredients together: L-citrulline DL-malate, L-arginine AKG, L-arginine HCl. Single amounts are not shown.
Hydroxypropyl methylcellulose (the capsule), microcrystalline cellulose, magnesium stearate.
The standard asterisk statement: not evaluated by the FDA, not intended to diagnose, treat, cure or prevent any disease.
'Manufactured in an FDA registered facility.' Registration is not FDA approval.
Dose vs research06
It is well below what blood pressure trials used. Even the most generous reading of the label falls short.
Probably not, if the trials are the guide. Two capsules give 1 g of blend a day. Citrulline trials started at 3 g, and arginine trials at 4 g (Barkhidarian 2019, citrulline meta-analysis) (Dong 2011, arginine meta-analysis).
The label hides each line's amount. But in a 500 mg blend of three, listed by weight, citrulline holds 167 to 500 mg, and the two arginine forms share at most 333 mg. Part of each weight is the salt partner, too.
| Ingredient | Evidence | What it found |
|---|---|---|
| L-arginine | 11 trials, 387 people (Dong 2011, arginine meta-analysis) | About 5.4/2.7 mm Hg lower at 4-24 g a day |
| L-citrulline | 8 trials (Barkhidarian 2019, citrulline meta-analysis) | About 4.1 mm Hg lower systolic at 3-9 g a day; diastolic change not significant |
| Citrulline vs arginine | Dosing study (Schwedhelm 2008, citrulline kinetics) | Oral citrulline raised blood arginine more than oral arginine did |
| Arginine after a heart attack | VINTAGE MI trial (VINTAGE MI trial, JAMA 2006) | Stopped early: 6 deaths on arginine, none on placebo |
| Citrulline for exercise | 12 studies (Trexler 2019, citrulline exercise) | A small strength and power benefit at 3 g or more |
The step-by-step math is on the Melonex dose check page, and the two amino acids are compared in arginine vs citrulline.
Label claims07
Three icons on the label and one line on the sales page, each next to what studies of the ingredients found.
They are structure/function claims, the kind a supplement may print with the FDA disclaimer. A seller must have support for them but does not need FDA approval first (FDA, structure/function claims).
They are not claims to treat high blood pressure or heart disease. Only a drug may make those (FDA, structure/function claims).
Claim 1Label says“Heart Support*”
What the evidence saysA structure/function phrase. Arginine trials looked at blood pressure and vessel function, not heart disease outcomes; after a heart attack, arginine is advised against. (Mayo Clinic, L-arginine) (VINTAGE MI trial, JAMA 2006) (FDA, structure/function claims)
Claim 2Label says“Circulation Support*”
What the evidence saysArginine is the raw material for nitric oxide, which relaxes blood vessels, and citrulline raises blood arginine. Trial doses were grams a day. (Cziraki 2020, arginine-NO pathway) (Schwedhelm 2008, citrulline kinetics) (Barkhidarian 2019, citrulline meta-analysis)
Claim 3Label says“Natural Formula*”
What the evidence saysThree amino acid forms plus a plant-cellulose capsule. The label does not define 'natural' or name a source for the amino acids. (21 CFR 184.1440, magnesium stearate)
Claim 4Sales page says“Healthy blood pressure”
What the evidence saysPooled trials of arginine (4-24 g a day) and citrulline found small drops in readings. No trial used 0.5-1 g of this blend. (Dong 2011, arginine meta-analysis) (Barkhidarian 2019, citrulline meta-analysis) (NCCIH, hypertension digest)
Icons cropped from the Melonex label; the fourth image is the label front. Claims as worded on the label and the sales page (Melonex sales page).
Safety08
Five questions. A yes means a talk with your doctor or pharmacist first, and two of them mean do not start.
Anyone who has had a heart attack should not start Melonex without their cardiologist. In the VINTAGE MI trial, arginine after a heart attack was stopped early when six patients on it died and none on placebo did (VINTAGE MI trial, JAMA 2006).
People on blood pressure medicine, nitrates or erectile-dysfunction drugs need a doctor's view first, because arginine may make pressure drop too low (Mayo Clinic, L-arginine). So do pregnant or nursing women and anyone under 18, as the label itself says.
Arginine may raise potassium and should not be combined with potassium-sparing diuretics; it may add to blood thinners and diabetes drugs (Mayo Clinic, L-arginine). Avoid it during an active herpes outbreak (Health Library, Arginine). More on side effects and interactions.
Know your numbers09
The five categories the American Heart Association uses, a reading finder, and the signs that need 911.
A normal reading is under 120 systolic and under 80 diastolic. Stage 1 high blood pressure starts at 130 or 80, and stage 2 at 140 or 90 (AHA, blood pressure readings).
About 48% of U.S. adults have high blood pressure, and only about 1 in 4 of them has it under control (CDC, high blood pressure facts). Knowing your own numbers, measured at home the right way, is worth more than any capsule (AHA, home BP monitoring).
Type both numbers from one reading to see its category. One reading is not a diagnosis; a doctor uses repeat readings.
Categories from the American Heart Association (AHA, blood pressure readings). Nearly half of U.S. adults have high blood pressure (CDC, high blood pressure facts). A reading over 180/120 with chest pain, shortness of breath, back pain, weakness, vision change or trouble speaking needs 911.
Call 911Any of these signs, even if they go away. Note the time they started. Do not drive yourself to the hospital.
Low?Dizzy, light-headed, blurry vision or fainting, especially on standing, can mean blood pressure fell too low. Sit or lie down and call your doctor.
Warning signs from the American Heart Association (AHA, warning signs); low blood pressure signs from NHLBI (NHLBI, low blood pressure). Arginine and citrulline can lower blood pressure, more so with nitrates or erectile-dysfunction drugs (Mayo Clinic, L-arginine).
More in blood pressure numbers and heart health habits.
Name mix-up10
No. A meloxicam painkiller is sold as Melonex in some countries. These capsules contain no meloxicam.
No, Melonex capsules are not meloxicam. Meloxicam is a prescription NSAID painkiller with a boxed warning for heart attack, stroke and stomach bleeding (MedlinePlus, meloxicam). Melonex capsules are amino acids.
Searches for "Melonex injection", "Melonex oral suspension" or "Melonex for dogs" are almost always about that veterinary or prescription meloxicam. We give no doses for it. A vet sets an animal's dose, and repeated meloxicam can cause kidney failure in cats (FDA, pain relievers for pets).
Dietary supplement for adults. L-citrulline and L-arginine, 500 mg a capsule. Sold online in the US. Not for animals.
A prescription NSAID sold as tablets, injections and suspensions, including for animals. Ask your doctor or vet about it, not a supplement seller.
The full comparison is on Melonex vs meloxicam, and pet questions are answered on Melonex and pets.
Verdict11
The pros are a short, readable label, an easy routine and a 60-day guarantee. The cons are no product trial, small doses and a hidden split inside the blend.
Our view: a simple amino acid capsule with a modest dose and honest-looking packaging. Treat it as a supplement, never as blood pressure care.
Prices12
$158 for two bottles plus $9.99 shipping, $207 for three and $294 for six, with free US shipping on the bigger packs.
Melonex costs $79 a bottle in the 2-bottle pack, $69 in the 3-bottle pack and $49 in the 6-bottle pack (Melonex sales page). At one capsule a day, a 6-pack works out to about $0.82 a day.
There are no bonuses, no subscription is offered on the sales page, and we never show the struck "was" prices.
Starter

$158total
$79 a bottle
$9.99 shipping
Free US shipping

$207total
$69 a bottle
Free US shipping
Lowest per bottle

$294total
$49 a bottle
Free US shipping
Prices on the Melonex sales page, October 18, 2026 (Melonex sales page). The 2-bottle pack adds $9.99 shipping ($167.99 in all); 3 and 6 bottles ship free in the US. Per-day figures use 30 days a bottle at 2 capsules and 60 at 1. We never show the struck "was" prices or the "you save" lines; the checkout shows the final total.
You need 3 bottles. The 3-bottle pack covers it for $207 ($69 a bottle), with free US shipping.
Uses the sales-page prices: $158 for 2 bottles plus $9.99 shipping, $207 for 3 and $294 for 6. Bottle icons fill one per bottle. A planning aid only; the checkout shows the final total.
Order buttons go to the Melonex checkout, where these prices and the guarantee apply. See pricing and where to buy.
Guarantee13
Money back within 60 days. The sales page asks you to use the capsules for at least 30 days first.
The sales page promises "100% Satisfaction or Your Money Back" for 60 days and asks for at least 30 days of continuous use before you contact customer service (Melonex sales page).
Your order ID is what the desk needs. The 60 days count from the order.
The sales page asks for at least 30 days of continuous use before you contact customer service. Keep your prescribed medicine going the whole time.
Call +1 (855) 889-3137 with your order ID before day 60. The bottle lists [email protected] as its email.
Send the bottles to the returns address with your full name, email and order ID. Return postage is on you.
Refunds post 3-5 business days after the bottles are credited, then 5-10 days on your card. Return shipping is on you. Read the guarantee and the refund policy.
Reviews14
We publish a review only after it is matched to a real order and the buyer agrees. None is verified yet.
No Melonex review on this site is verified yet, so the cards are empty slots. The photos were supplied by the vendor and are shown small.
The seller's sample scores, order counts and named reviewers are left out. The FTC bans fake reviews and testimonials (FTC, fake reviews rule), and stories are never proof that a product works (FTC, health products guidance).
4.4out of 5
Based on 1,014 verified ratings
Filled in only from reviews matched to a real order. How we check reviews.

I keep a notebook by the kettle. Phone on the pack is +1 (855) 889-3137. They had the order ID. I keep it on the bleacher tote. I take it after I hang the keys.
Pack review 1, as supplied · Photo supplied by the vendor

I do laundry for the house. That's the cue. Capsule with water. Cuff at the clinic is still the score. I don't skip that visit. I keep it by the hymnals. I take it when I open the tackle box.
Pack review 2, as supplied · Photo supplied by the vendor

I keep a tackle box in the truck. Checkout had prices and a 60-day line. No panel. I waited for the bottle. I keep it in the tackle box. I take it when the ferry horn goes.
Pack review 3, as supplied · Photo supplied by the vendor
See how we check reviews.
Badges15
Five brand badges, each with what it does and does not show.
The badges are the seller's own artwork, not certificates. None names a certifier, a lab or an audit date. Two of them match words on the label: the FDA registered facility line and the made-in-USA line.

A brand badge. The label names no factory, certifier or audit date.

The label says it was made in an FDA registered facility. Registration is not approval.

Matches the label: made in the USA with globally sourced ingredients. Countries are not named.

A brand badge. No outside certification is printed on the label.

Matches the 60-day guarantee; the sales page asks for 30 days of use first.
Each badge comes from the brand's own image set. A badge is a claim by the seller, not a certificate: none names a certifier, lab or audit. FDA does not approve supplements before they are sold (FDA, supplement Q&A), and health claims in ads need real evidence (FTC, health products guidance).
Melonex is distributed for Instituto Experience of Lakeland, Florida; the maker is not named. Gomelonex is a USA authorized retailer, not the maker, and earns money from our order links. Lot code M-26/GO-5347 is a seller reference, not lab proof. Read about us and is Melonex legit?
FAQ16
No question matches. Try another word.
Melonex is sold as a heart and circulation support supplement. The label claims 'Heart Support*' and 'Circulation Support*', and the sales page adds blood pressure wellness. It is not a medicine for any disease, and it is not the meloxicam painkiller of the same name (FDA, structure/function claims) (MedlinePlus, meloxicam).
A 500 mg proprietary blend of L-citrulline DL-malate, L-arginine alpha-ketoglutarate dihydrate and L-arginine HCl, in a hydroxypropyl methylcellulose capsule with microcrystalline cellulose and magnesium stearate.
One capsule a day with an 8 oz glass of water. The label says you may take up to two a day. Do not take more than two.
No study has tested Melonex. Its ingredients lowered blood pressure slightly in trials at 3-24 g a day (Dong 2011, arginine meta-analysis) (Barkhidarian 2019, citrulline meta-analysis); one capsule holds 0.5 g of blend. Expect a small dose of well-known amino acids, not a treatment.
For most healthy adults, arginine and citrulline are usually well tolerated at modest doses, though stomach upset can happen (Mayo Clinic, L-arginine). Do not use it after a heart attack, and ask your doctor first if you take blood pressure drugs, nitrates or sildenafil.
No. These capsules are for adults. The pet product sold as Melonex in some countries is meloxicam, a different drug that only a vet should dose; repeated meloxicam can cause kidney failure in cats (FDA, pain relievers for pets).
Two bottles are $158 ($79 each) plus $9.99 shipping, three are $207 ($69 each) and six are $294 ($49 each), with free US shipping on 3 and 6. That is about $2.63, $2.30 or $1.63 a day at two capsules.
The Melonex label desk writes them. The medical reviewer is not named yet, and the box at the bottom of each page shows where those details will appear once a review is on file.
USA authorized Melonex retailer
Check your medicines first, then pick a pack. Three or six bottles ship free in the US and cost less per bottle, and the 60-day guarantee opens after 30 days of use.
